Grey literature usually doesn't go through the formal peer review process that other research does. This means the reliability of the information can vary. This makes it very important to evaluate the quality of grey literature.
When evaluating preprints, consider these additional elements:
Appraisal tools exist for specific study types such as randomised controlled trials and other types of clinical trials. The same tools apply whether they are published or unpublished.
While there are no specific appraisal tools for grey literature generally, the AACODS checklist considers key elements for reviewing grey literature other than clinical trials. These include the authority of the creator and the sharing organisation, accuracy and objectivity of the content, date of creation and significance of the content.